a1 Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Family histories obtained from 27 patients with obsessive-compulsive disorder failed to find a single parent with the disorder. To augment the family history data the Leyton Obsessional Inventory was completed by a subset of 10 patients and by their 20 parents. Although as a group parents showed lower Leyton Obsessional Inventory symptom scores than their obsessional offspring, 3 parents who had not been identified by family history were distinguished by high symptom scores in the absence of significant resistance or interference.
c1 Address for correspondence: Dr T. R. Insel, National Institute of Mental Health, NIH Clinical Center, Building 10, Room 3D41, Bethesda, MD 20205, USA.