Psychological Medicine

Research Article

Parents of patients with obsessive-compulsive disorder

Thomas R. Insela1 c1, Carol Hoovera1 and Dennis L. Murphy

a1 Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland, USA


Family histories obtained from 27 patients with obsessive-compulsive disorder failed to find a single parent with the disorder. To augment the family history data the Leyton Obsessional Inventory was completed by a subset of 10 patients and by their 20 parents. Although as a group parents showed lower Leyton Obsessional Inventory symptom scores than their obsessional offspring, 3 parents who had not been identified by family history were distinguished by high symptom scores in the absence of significant resistance or interference.


c1 Address for correspondence: Dr T. R. Insel, National Institute of Mental Health, NIH Clinical Center, Building 10, Room 3D41, Bethesda, MD 20205, USA.