British Journal of Nutrition

Full Papers

Human and Clinical Nutrition

Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety

K. Laitinena1a2 c1, E. Isolauria3a4, L. Kaipiainena5, H. Gyllinga6a7 and T.A. Miettinena5

a1 Department of Biochemistry and Food Chemistry, University of Turku, 20014 Turku, Finland

a2 Functional Foods Forum, University of Turku, 20014 Turku, Finland

a3 Department of Paediatrics, Turku University Central Hospital, Turku, Finland

a4 Department of Paediatrics, University of Turku, 20014 Turku, Finland

a5 Division of Internal Medicine, Department of Medicine, University of Helsinki, 00014 Helsinki, Finland

a6 Kuopio University Hospital, 70211 Kuopio, Finland

a7 School of Public Health and Clinical Nutrition, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland

Abstract

Clinical safety of consuming plant stanol ester spreads during pregnancy and lactation, the impact on maternal and infant serum and breast-milk cholesterol and the ratios (μmol/mmol of cholesterol) of synthesis and absorption markers were evaluated. Pregnant women (n 21) were randomised to control and dietary intervention groups, the intervention including advice to follow a balanced diet and to consume spreads enriched with plant stanol esters. Participants were followed during and after pregnancy and their infants up to 1 year of age. A mean 1·1 (sd 0·4) g consumption of plant stanols during pregnancy and 1·4 (sd 0·9) g 1 month post-partum increased sitostanol and the markers for cholesterol synthesis, lathosterol, lathosterol/campesterol and lathosterol/sitosterol, and reduced a marker for cholesterol absorption, campesterol, in maternal serum. In breast milk, desmosterol was lower in the intervention group, while no differences were detected between the groups in infants' serum. Plant stanol ester spread consumption had no impact on the length of gestation, infants' growth or serum β-carotene concentration at 1 and 6 months of age, but the cholesterol-adjusted serum β-carotene concentration was lowered at 1 month in the intervention group. Plant stanol ester spread consumption appeared safe in the clinical setting, except for potential lowering of infants' serum β-carotene concentration, and was reflected in the markers of cholesterol synthesis and absorption in mothers' serum, encouraging further studies in larger settings.

(Received June 19 2008)

(Revised October 02 2008)

(Accepted October 15 2008)

(Online publication November 19 2008)

Correspondence:

c1 Corresponding author: Kirsi Laitinen, fax +358 2 333 6862, email kirsi.laitinen@utu.fi

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