Epidemiology and Infection

Research Article

Nephropathia epidemica: incidence of clinical cases and antibody prevalence in an endemic area of Sweden

B. Niklassona1, J. Leduca2, K. Nyströma3 and L. Nymana4

a1 Department of Virology, National Bacteriological Laboratory, S-105 21 Stockholm, Sweden and National Defense Research Institute FOA-5, Box 27322, S-102 54, Stockholm, Sweden

a2 Medical Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21701, USA

a3 Department of Medicine, Umexs0227 Hospital, S-901 87 Umexs0227, Sweden

a4 Department of Infectious Diseases, Visby Hospital, S-621 84, Visby, Sweden


The incidence of nephropathia epidemica (NE) was compared with the NE antibody prevalence in normal population in a highly endemic area of Sweden (Västerbotten county). The antibody prevalence rate in the oldest age groups were found to be 14 and 20 times higher than the accumulated life-risk of being hospitalized with NE for men and women respectively. Whether the infection in persons not admitted to hospital is subclinical, atypical or clinically fulminant, remains to be determined.

(Accepted May 19 1987)