Hostname: page-component-7c8c6479df-hgkh8 Total loading time: 0 Render date: 2024-03-27T19:17:26.907Z Has data issue: false hasContentIssue false

Infection with influenza A H1N1: 2. The effect of past experience on natural challenge

Published online by Cambridge University Press:  19 October 2009

J. R. Davies
Affiliation:
Influenza Research Unit, PHLS Laboratory, St Lukes Hospital, Guildford, Surrey GU1 3NT
E. A. Grilli
Affiliation:
Influenza Research Unit, PHLS Laboratory, St Lukes Hospital, Guildford, Surrey GU1 3NT
A. J. Smith
Affiliation:
Influenza Research Unit, PHLS Laboratory, St Lukes Hospital, Guildford, Surrey GU1 3NT
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Following its reintroduction in 1978 influenza A H1N1 spread widely in the child population. By the autumn of 1979, 75% of 11-year olds entering a boys' boarding school had detectable antibody. The protective effect of previous experience could be assessed during two outbreaks in the school. In the first outbreak in 1979, 90% of those known to have been infected in the previous year were protected against reinfection. In 1983 after strains of the H1N1 subtype had undergone antigenic drift a large outbreak occurred. It was estimated that past infection conferred protection against clinical influenza in 55%. Where past infection resulted in the presence of antibody which reacted with the outbreak strain the attack rate was further reduced. A large number of sub-clinical infections was detected in all groups.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1986

References

REFERENCES

Al-Khayatt, R., Jennings, R. & Potter, C. W. (1984). Interpretation of responses and protective levels of antibody against attenuated influenza A using single radial haemolysis. Journal of Hygiene 92, 301312.CrossRefGoogle Scholar
Davies, J. R., Smith, A. J., Grilli, E. A. & Hoskins, T. W. (1982). Christ's Hospital 1978–79: an account of two outbreaks of influenza A H1N1. Journal of Infection 5, 151156.CrossRefGoogle Scholar
Feery, B. J., Gallichio, H. A., Rodda, S. J. & Hampson, A. W. (1979). Antibody responses to influenza vaccines containing A/USSR/90/77. Australian Journal of Experimental Biology and Medical Science 57, 335344.CrossRefGoogle ScholarPubMed
Grilli, E. A., Davies, J. R. & Smith, A. J. (1980). Infection with influenza A H1N1. 1. Production and persistence of antibody. Journal of Hygiene 96, 335343.CrossRefGoogle Scholar
Hoskins, T. W., Davies, J. R., Smith, A. J., Miller, C. L. & Allchin, A. (1979). Assessment of influenza A vaccine after three outbreaks of influenza A at Christ's Hospital. Lancet i, 3335.CrossRefGoogle Scholar
Potter, C. W., Clark, A., Jennings, R., Schild, G. C., Wood, J. M. & McWilliam, P. K. A. (1980). Reactogenicity and immunogenicity of inactivated influenza A (H1N1) virus vaccine in unprimed children. Journal of Biological Standardization 8, 3548.CrossRefGoogle ScholarPubMed