CJO - Abstract - Serum ferritin, cardiovascular risk factors and ischaemic heart diseases: a prospective analysis in the SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) cohort

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    Serum ferritin, cardiovascular risk factors and ischaemic heart diseases: a prospective analysis in the SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) cohort
    Pilar Galan, Nathalie Noisette, Carla Estaquio, Sebastien Czernichow, Louise Mennen, Jean-Charles Renversez, Serge Briançon, Alain Favier and Serge Hercberg (2006).
    Public Health Nutrition, Volume 9, Issue 01, February 2006 pp 70-74 http://journals.cambridge.org/action/displayAbstract?aid=584024

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Public Health Nutrition (2006), 9 : 70-74 Cambridge University Press
doi:10.1079/PHN2005826 (About doi)
Published online by Cambridge University Press 02 Jan 2007
 
Cambridge Journals Online - CUP Full-Text Page
Public Health Nutrition (2006), 9:70-74 Cambridge University Press
Copyright © The Authors 2006
doi:10.1079/PHN2005826

Research Article

Serum ferritin, cardiovascular risk factors and ischaemic heart diseases: a prospective analysis in the SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) cohort

Pilar Galana1 c1, Nathalie Noisettea1, Carla Estaquioa1, Sebastien Czernichowa1, Louise Mennena1, Jean-Charles Renverseza2, Serge Briançona3, Alain Faviera2a4 and Serge Hercberga1a5

a1 U557 INSERM (UMR INSERM/INRA/CNAM), Centre de Recherche en Nutrition, Ile de France, Paris 13, Bobigny, France
a2 Département de Biologie Intégrée, CHU de Grenoble, France
a3 Ecole de Santé Publique, Epidémiologie clinique, Faculté de Médecine, CHU Nancy EA 3444, France
a4 Laboratoire Lésions des Acides Nucléiques, UMR CNRS-CEA-UJF 5046, Grenoble, France
a5 Unité de Surveillance et d'Epidémiologie Nutritionnelle, INVS/CNAM, Paris, France
Article author query
galan p PubMed  Google Scholar
noisette n PubMed  Google Scholar
estaquio c PubMed  Google Scholar
czernichow s PubMed  Google Scholar
mennen l PubMed  Google Scholar
renversez j PubMed  Google Scholar
briançon s PubMed  Google Scholar
favier a PubMed  Google Scholar
hercberg s PubMed  Google Scholar

Abstract

Background Iron has been suggested to play a role in the development of cardiovascular disease (CVD) through its pro-oxidant properties. However, epidemiological studies on iron status and the risk of CVD have yielded conflicting results. We therefore carried out a prospective study to evaluate the relationship between iron status and CVD in a middle-aged French population.

Methods In total, 9917 subjects (3223 men aged 45–60 years and 6694 women aged 35–60 years) included in the SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) cohort were followed prospectively for 7.5 years. All cases of ischaemic heart disease (IHD) were identified and validated. CVD risk factors, haemoglobin and serum ferritin concentrations were measured at baseline.

Findings Of men 4.3%, and of women 37.8%, presented at baseline a serum ferritin concentration <30 μg l−1. During the follow-up, 187 subjects (148 men, 39 women) developed IHD. Serum ferritin was positively associated with total cholesterol, serum triglycerides, systolic and diastolic blood pressure, body mass index and haemoglobin. No linear association was found between serum ferritin and IHD risk in men or in women.

Conclusion Our data do not support a major role of iron status in the development of IHD in a healthy general population.

(Received November 03 2004)

(Accepted June 14 2005)

Key Words: Iron; Serum ferritin; Ischaemic heart disease; Prospective study

Correspondence:

c1 *Corresponding author: Email pilar.galan@cnam.fr

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