a1 Department of Bacteriology, Institute of Dermatology, London E9 6BX
The co-transfer of plasmid-borne genes governing resistance to gentamicin, tetracycline, erythromycin and chloramphenicol has been demonstrated on human and mouse skin. Two different gentamicin resistance plasmids have been studied in detail; both appear to have the ability to mobilize in vivo otherwise non-transferable resistance plasmids from coagulase-negative to coagulase-positive staphylococci. This emphasises the role of the skin in maintaining a pool of resistance genes available to pathogenic staphylococci.
(Received January 24 1984)
(Accepted February 15 1984)