British Journal of Nutrition

Review Article

Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation

Christian Oudshoorna1, Tischa J. M. van der Cammena1, Marion E. T. McMurdoa2, Johannes P. T. M. van Leeuwena3 and Edgar M. Colina4 c1

a1 Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

a2 Section of Ageing and Health, Department of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK

a3 Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

a4 Department of Rheumatology, Erasmus University Medical Center, Room EE 959a, 's Gravendijkwal 230, 3000 CA Rotterdam, The Netherlands

Abstract

Vitamin D is a fat-soluble, seco-steroid hormone. In man, the vitamin D receptor is expressed in almost all tissues, enabling effects in multiple systems of the human body. These effects can be endocrine, paracrine and autocrine. The present review summarises the effects of ageing on the vitamin D endocrine system and on Ca homeostasis. Furthermore, consequences for vitamin D supplementation are discussed.

(Received August 06 2008)

(Revised January 12 2009)

(Accepted March 12 2009)

(Online publication April 27 2009)

Correspondence:

c1 Corresponding author: Edgar M. Colin, fax +31 10 704 4593, email e.colin@erasmusmc.nl

Footnotes

Abbreviations: FGF-23, fibroblast growth factor-23; PTH, parathyroid hormone; TRPV, transient receptor potential vanilloid; VDR, vitamin D receptor; 1α-OHase, 1α-hydroxylase; 1,25(OH)2D3, 1,25-dihydroxyvitamin D3; 24OHase, 24-hydroxylase; 25OHD3, 25-hydroxyvitamin D3

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