Annals of Human Genetics

Northwest African distribution of the CD4/Alu microsatellite haplotypes

C. FLORES a1, N. MACA-MEYER a1, A. M. GONZÁLEZ a1 and V. M. CABRERA a1c1
a1 Departamento de Genética, Universidad de La Laguna, E-38271 La Laguna, Tenerife, Spain


We have analysed a linked microsatellite/Alu polymorphism at the CD4 locus (CD4/Alu) in 666 chromosomes from samples of the Iberian Peninsula, Northwest Africa, and West sub-Saharan Africa. The Iberian Peninsula differs from other European populations by its higher levels of haplotype diversity (0.75), and weaker association between the microsatellite allele 90 and Alu(−) chromosomes. These results are explainable by a substantial gene flow from Northwest Africa. Significant geographic clines for the five major haplotypes suggest a south to north migration from sub-Saharan Africa into Northwest Africa. In spite of this, the consistent presence of haplotype 110(−) in this area is congruent with an ancient and autochthonous human presence in Northwest Africa.

(Received February 14 00)
(Accepted May 5 00)

c1 Correspondence: Dr Vicente M. Cabrera, Departamento de Genética, Facultad de Biología, Universidad de La Laguna, E-38271 La Laguna, Tenerife, Spain. Tel: +34 922 318350; Fax: +34 922 318311; E-mail: