European Journal of Anaesthesiology



Review

Aprotinin; friend or foe? A review of recent medical literature


D. Royston a1c1, N. van Haaften a1 and P. De Vooght a1
a1 Royal Brompton and Harefield NHS Trust, Harefield Hospital, Department of Cardiothoracic Anaesthesiaand Critical Care, Harefield, UK

Article author query
royston d   [PubMed][Google Scholar] 
van haaften n   [PubMed][Google Scholar] 
de vooght p   [PubMed][Google Scholar] 

Summary

Recent articles published in peer review journals have questioned the safety of using aprotinin in patients having heart surgery. Also, evidence has been published to suggest an increase in renal events in patients given aprotinin when compared to those where tranexamic acid was used. The present review will focus principally on the first of these articles in relation to previously published data and experience.

(Accepted October 4 2006)
(First published online November 14 2006)


Key Words: APROTININ; CARDIAC SURGICAL PROCEDURES; REVIEW, LITERATURE; TRANEXAMIC ACID; ADVERSE EFFECTS; BLOOD TRANSFUSION.

Correspondence:
c1 Correspondence to: David Royston, Department of Anaesthesia and Critical Care, Royal Brompton and Harefield NHS Trust, Harefield Hospital, Hill End Road, Harefield, Middlesex, UB9 6JH, UK. E-mail: dave@tharg.demon.co.uk; Tel: +44 1895 828946; Fax: +44 1895 828965