Parasitology



Further evaluation of the synthetic peptide vaccine S3Pvac against Taenia solium cysticercosis in pigs in an endemic town of Mexico


E. SCIUTTO a1c1, J. MORALES a2, J. J. MARTÍNEZ a2, A. TOLEDO a1, M. N. VILLALOBOS a2, C. CRUZ-REVILLA a1, G. MENESES a1, M. HERNÁNDEZ a1, A. DÍAZ a5, L. F. RODARTE a2, G. ACERO a1, G. GEVORKIAN a1, K. MANOUTCHARIAN a1, J. PANIAGUA a4, G. FRAGOSO a1, A. FLEURY a3, R. LARRALDE a1, A. S. DE ALUJA a2 and C. LARRALDE a1
a1 Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, Ciudad Universitaria, 04510 México, D.F. México
a2 Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Circuito de la Investigación Científica, Ciudad Universitaria, 04510 México, D.F. México
a3 Instituto Nacional de Neurología y Neurocirugía, Insurgentes Sur 3877, Col. Las Famas, 14269 México, D.F. México
a4 Laboratorios Silanes, Amores # 1304, Col. Del Valle, México, D.F. México
a5 Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, México

Article author query
sciutto e   [PubMed][Google Scholar] 
morales j   [PubMed][Google Scholar] 
martinez jj   [PubMed][Google Scholar] 
toledo a   [PubMed][Google Scholar] 
villalobos mn   [PubMed][Google Scholar] 
cruz-revilla c   [PubMed][Google Scholar] 
meneses g   [PubMed][Google Scholar] 
hernandez m   [PubMed][Google Scholar] 
diaz a   [PubMed][Google Scholar] 
rodarte lf   [PubMed][Google Scholar] 
acero g   [PubMed][Google Scholar] 
gevorkian g   [PubMed][Google Scholar] 
manoutcharian k   [PubMed][Google Scholar] 
paniagua j   [PubMed][Google Scholar] 
fragoso g   [PubMed][Google Scholar] 
fleury a   [PubMed][Google Scholar] 
larralde r   [PubMed][Google Scholar] 
de aluja as   [PubMed][Google Scholar] 
larralde c   [PubMed][Google Scholar] 

Abstract

Taenia solium cysticercosis is a parasitic disease frequently affecting human health and the pig industry in many developing countries. A synthetic peptide vaccine (designated S3Pvac) against porcine cysticercosis has been developed previously as an aid to interrupt transmission and has been shown to be effective. The results of the present study support the effectiveness of the vaccine under endemic field conditions. However, given the time-frame of the vaccination trial, no changes in the local levels of transmission were detectable before and after vaccination using sentinel pigs. Thus, this investigation shows the limited usefulness of single vaccination as the sole means of interrupting Taenia solium transmission in an endemic region.

(Received June 14 2006)
(Accepted July 4 2006)
(Published Online September 4 2006)


Key Words: Taenia solium; cysticercosis; control; vaccination; field evaluation.

Correspondence:
c1 Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P. 70228, Ciudad Universitaria, 04510 México, D.F. México. Tel: +5255 5622 3153. Fax: +5255 5622 3369. E-mail: edda@servidor.unam.mx


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