British Journal of Nutrition

Full Papers

Human and Clinical Nutrition

Maternal weight and lean body mass may influence the lactation-related bone changes in young undernourished Indian women

Bharati Kulkarnia1 c1, Veena Shatrugnaa1, Balakrishna Nagallaa1, P. Ajeya Kumara1, K. Usha Rania1 and A. Chandrakala Omkara1

a1 National Institute of Nutrition (Indian Council of Medical Research), Jamai Osmania PO, Hyderabad 500 007, India

Abstract

Lactation is known to be associated with a transient loss of bone mineral density (BMD) during 3–6 months post-partum. Bone changes during lactation in women consuming low dietary calcium are not sufficiently studied. The present longitudinal study examined the BMD changes during lactation in undernourished women and the relationship of bone changes to the nutritional status. Whole-body bone mineral content and BMD at hip, lumbar spine and forearm were assessed using dual-energy X-ray absorptiometry in thirty-six lactating women from the low socio-economic group at four time points – within 1 month after delivery (baseline), and at 6, 12 and 18 months after delivery. Maternal body composition and biochemical parameters of bone metabolism were estimated at the same time. It was observed that femoral neck BMD reduced by 4·6 % at 6 months, but recovery to the baseline was incomplete at 18 months with a deficit of 2 %. Hip BMD reduction at 6 months was transient. Lumbar spine BMD did not show significant loss at 6 months and BMD increased by 3·6 and 6·3 % at 12 and 18 months, respectively. Regression analyses indicated that baseline lean mass was the most important determinant of bone preservation at femoral neck, hip as well as whole body, whereas baseline body weight was the most important determinant of per cent gain in lumbar spine. Maternal nutritional status as indicated by body weight and lean mass appears to influence the lactation-related BMD changes in undernourished women from the low socio-economic group in India.

(Received February 08 2008)

(Revised July 07 2008)

(Accepted September 02 2008)

(Online publication October 30 2008)

Correspondence:

c1 Corresponding author: Dr Bharati Kulkarni, fax +91 40 27019074, email bharati70@yahoo.com

Footnotes

Abbreviations: BA, bone area; BMD, bone mineral density; BMC, bone mineral content; LS-BMB, lumbar spine bone mineral density; PBM, peak bone mass