a1 Department of Medicine, Hjørring/Brønderslev Hospital, DK-9800, Hjørring, Denmark.
a2 Department of Nephrology, Aalborg Hospital, DK-9800, Aalborg, Denmark
a3 Department of Medi-Lab A/S, DK1001, Copenhagen, Denmark.
Objective To review and discuss the effect of n-3 polyunsaturated fatty acids (PUFA) from fish in the prevention and, primarily, in the treatment of coronary artery disease (CAD).
Design Overview of the literature.
Results There is good evidence that fish consumption may reduce the risk of CAD.
Conclusions Fish can be recommended to reduce the risk of CAD both in healthy subjects and in patients with a high risk of CAD or with documented CAD. The use of fish oil concentrates can not be recommended in general, but may be considered in patients after a myocardial infarction or in patients with hypertriglyceridaemia. An increased intake of n-3 polyunsaturated fatty acids from fish may have substantial implications for public health and health economy by decreasing the risk of coronary events and sudden cardiac death.
(Received February 01 1999)
(Accepted August 12 1999)