a1 Section of Women's Health and Preventive Medicine, Departments of Obstetrics/Gynecology and Medicine (Cardiology), Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA
Metabolic abnormalities in patients with PCO syndrome demand that we change our clinical approach to PCO syndrome. No longer should the approach be short-term and driven by symptoms, rather it must recognize that PCO syndrome is a chronic disorder. Associated metabolic abnormalities may have long-term sequelae and their recognition influences not only how we evaluate patients, but also how we implement prevention. Observational, interventional, epidemiological and now mechanistic studies need to focus on interactive issues. Outcome study results are awaited to determine the likelihood of sequelae and to optimize preventive strategies. The PCO paradigm is a complex biological experiment on nature that offers a superb opportunity to begin to understand the many ways in which hormones affect atherogenesis. It is important to understand the clinical syndromes encompassed in this paradigm. Atherogenic consequences are still responsible for the majority of deaths in the industrialized world!
c1 Section of Women's Health and Preventive Medicine, Departments of Obstetrics/Gynecology and Medicine (Cardiology), Oklahoma University Health Sciences Center, 920 S. Stanton L. Young Blvd., WP2410; Oklahoma City, Oklahoma 73104, USA.