Epidemiology and Infection



Predicting the emergence of human hantavirus disease using a combination of viral dynamics and rodent demographic patterns


F. SAUVAGE a1, M. LANGLAIS a2 and D. PONTIER a1c1
a1 UMR–CNRS 5558 ‘Biométrie et Biologie évolutive’, Université C. Bernard Lyon-1, Villeurbanne, France
a2 UMR–CNRS 5466 ‘Mathématiques Appliquées de Bordeaux’, Université Victor Segalen Bordeaux 2 – case 26, Bordeaux, France

Article author query
sauvage f   [PubMed][Google Scholar] 
langlais m   [PubMed][Google Scholar] 
pontier d   [PubMed][Google Scholar] 

Abstract

The paper proposes a model explaining the spatial variation in incidence of nephropathia epidemica in Europe. We take into account the rodent dynamic features and the replicative dynamics of the virus in animals, high in the acute phase of newly infected animals and low in the subsequent chronic phase. The model revealed that only vole populations with multi-annual fluctuations allow for simultaneously high numbers of infected rodents and high proportions of those rodents in the acute excretion phase during the culminating phase of population build-up. This leads to a brief peak in exceptionally high concentrations of virus in the environment, and thereby, to human exposure. Such a mechanism suggests that a slight ecological disturbance in animal–parasite systems could result in the emergence of human diseases. Thus, the potential risk for public health due to several zoonotic diseases may be greater than previously believed, based solely on the distribution of human cases.

(Accepted April 4 2006)
(Published Online June 6 2006)


Correspondence:
c1 UMR-CNRS 5558 ‘Biométrie et Biologie évolutive’, Université C. Bernard Lyon-1, 43 Bd du 11 novembre 1918, 69622 Villeurbanne cedex, France. (Email: dpontier@biomserv.univ-lyon1.fr)


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