Verbal working memory in HIV-seropositive drug users
Recent evidence suggests that HIV-seropositive drug users are impaired on tasks of visuospatial working memory compared with drug users seronegative for HIV. In the current study we evaluated the performance of 30 HIV-seropositive male drug users and 30 risk-matched seronegative controls on two measures of verbal working memory, the Listening Span and the verbal Self Ordered Pointing Task. Impaired working memory performance was significantly more common among HIV-seropositive persons compared to controls, with the highest incidence of deficit among symptomatic participants. These findings indicate that working memory deficits in persons with HIV are not domain-specific and can be demonstrated reliably in drug users. (JINS, 2000, 6, 548–555.)(Received May 5 1999)
(Revised July 19 1999)
(Accepted July 20 1999)
Key Words: HIV; Working memory; Drug abuse; Dementia; AIDS; Neuropsychological tests; Cognition.
c1 Reprint requests to: Eileen M. Martin, Department of Psychiatry (M/C 913), University of Illinois, 912 S. Wood Street, Chicago, IL 60612. E-mail: EMartin@psych.uic.edu
p1 Now at the Department of Psychiatry and Biobehavioral Sciences, University of California, Neuropsychiatric Institute, Los Angeles, California