Behavioral and Brain Sciences

Open Peer Commentary

High mental disorder rates are based on invalid measures: Questions about the claimed ubiquity of mutation-induced dysfunction

Jerome C. Wakefield a1
a1 School of Social Work, New York University, New York, NY 10003.

Article author query
wakefield jc   [PubMed][Google Scholar] 


Three reservations about Keller & Miller's (K&M's) argument are explored: Serious validity problems afflict epidemiological criteria discriminating disorders from non-disorders, so high rates may be misleading. Normal variation need not be mild disorder, contrary to a possible interpretation of K&M's article. And, rather than mutation-selection balance, true disorders may result from unselected combinations of normal variants over many loci.

(Published Online November 9 2006)