Behavioral and Brain Sciences

Open Peer Commentary

Reconciling the mutation-selection balance model with the schizotypy-creativity connection

Daniel Nettle a1
a1 Evolution and Behaviour Research Group, Division of Psychology, University of Newcastle, Newcastle NE2 4HH, United Kingdom.

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nettle d   [PubMed][Google Scholar] 


Keller & Miller (K&M) make a persuasive case for the role of mutation-selection balance in the persistence of such disorders as schizophrenia. However, there is evidence relating illness liability to creativity, which seems to imply balancing selection. I argue for a hybrid position, where schizotypal personality traits can have fitness advantages or disadvantages, with mutational load and neurodevelopmental conditions determining which outcome is observed.

(Published Online November 9 2006)