Behavioral and Brain Sciences

Open Peer Commentary

The romance of balancing selection versus the sober alternatives: Let the data rule

John J. McGrath a1
a1 Queensland Centre for Mental Health Research, University of Queensland, The Park Centre for Mental Health, Wacol, Queensland 4076, Australia

Article author query
mcgrath jj   [PubMed][Google Scholar] 


Schizophrenia has attracted more than its fair share of evolutionary-based theories. The theories involving balancing selection are based on the assumption that the incidence of schizophrenia is invariant across time and place. Modern epidemiology allows us to reject this dogmatic belief. Once variations in the genetic and epidemiological landscape of schizophrenia are acknowledged, more productive research models can be generated.

(Published Online November 9 2006)