Public Health Nutrition

Research Paper

Fish intake and the risk of fatal prostate cancer: findings from a cohort study in Japan

Truong-Minh Phama1a2 c1, Yoshihisa Fujinoa1, Tatsuhiko Kuboa3, Reiko Idea4, Noritaka Tokuia5, Tetsuya Mizouea6, Itsuro Ogimotoa7, Shinya Matsudaa1 and Takesumi Yoshimuraa8

a1 Department of Preventive Medicine and Community Health, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu-shi 807-8555, Japan

a2 Thai Nguyen Medical College, Thai Nguyen University, Thai Nguyen, Vietnam

a3 Asahi Kasei Nobeoka Office Health Care Center, Miyazaki, Japan

a4 Department of Work Systems and Health, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan

a5 Department of Preventive Medicine and Dietetics, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan

a6 Department of Epidemiology, Research Institute, International Medical Center of Japan, Tokyo, Japan

a7 Department of Public Health, School of Medicine, Kurume University, Kurume, Japan

a8 Fukuoka Institute of Health and Environmental Sciences, Fukuoka, Japan


Objective We investigated the relationship between the intake of fish and the risk of death from prostate cancer.

Design Data were derived from a prospective cohort study in Japan. Fish consumption obtained from a baseline questionnaire was classified into the two categories of ‘low intake’ and ‘high intake’. The Cox proportional hazards model was used to estimate hazard ratios (HR) and 95 % confidence intervals.

Subjects Data for 5589 men aged 30–79 years were analysed.

Results A total of twenty-one prostate cancer deaths were observed during 75 072 person-years of follow-up. Mean age at baseline study of these twenty-one subjects was 67·7 years, ranging from 47 and 79 years old. Results showed a consistent inverse association of this cancer between the high v. low intake groups. The multivariate model adjusted for potential confounding factors and some other food items showed a HR of 0·12 (95 % CI 0·05, 0·32) for the high intake group of fish consumption.

Conclusions These results support the hypothesis that a high intake of fish may decrease the risk of prostate cancer death. Given the paucity of studies examining the association between prostate cancer and fish consumption, particularly in Asian populations, these findings require confirmation in additional cohort studies.

(Received June 13 2007)

(Accepted May 02 2008)


c1 Corresponding author: Email;