Behavioral and Brain Sciences



Open Peer Commentary

Mutations, developmental instability, and the Red Queen


Steven W. Gangestad a1 and Ronald A. Yeo a1
a1 Department of Psychology, University of New Mexico, Albuquerque, NM 87111. sgangest@unm.edu ryeo@unm.edu

Article author query
gangestad sw   [PubMed][Google Scholar] 
yeo ra   [PubMed][Google Scholar] 

Abstract

We address two points. First, one must explain how different, rare mutations ultimately lead to common psychopathological conditions. The developmental instability model offers one solution. Second, Keller & Miller (K&M) perhaps miss the major processes other than variation fueled by rare deleterious mutations that account for interesting genetic variation in psychopathology, particularly when single alleles have non-negligible effects: Red Queen processes.

(Published Online November 9 2006)