a1 Department of Immunology, Trinity College Dublin and St James's Hospital, Dublin 8, Republic of Ireland
a2 Institute of Molecular Medicine & Department of Clinical Medicine, Trinity Centre for Health Science, St James's Hospital, Dublin 8, Republic of Ireland
Abstract
Over the past 20 years major advances have been made in the diagnosis and understanding of pathogenic mechanisms relating to coeliac disease. Recently-identified genetic markers support the immunological–inflammatory nature of the disease. It is hoped that these newly-identified genes will assist further dissection of the inflammatory pathways in coeliac disease and give insight into why certain individuals develop intolerance to dietary gluten.
(Online publication February 26 2009)
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Correspondence:
c1 Professor Conleth Feighery, fax +353 1 411 3008, email con.feighery@tcd.ie