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Drug-resistance in Plasmodium gallinaceum, and the persistence of paludrine-resistance after mosquito transmission

Published online by Cambridge University Press:  06 April 2009

Ann Bishop  and
Betty Birkett
Ann Bishop
Affiliation:
Molteno Institute, University of Cambridge
Betty Birkett
Affiliation:
Molteno Institute, University of Cambridge
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Extract

1. Attempts, made over a period of more than 6 months, to produce a strain of Plasmodium gallinaceum resistant to mepacrine failed.

2. A strain of P. gallinaceum resistant to daily doses of 0·08 mg./20 g. of pamaquin was obtained after approximately 8 months' treatment with the drug.

3. A strain of P. gallinaceum resistant to the maximum dose of paludrine which the chicks would tolerate (1·0 mg./20 g. twice daily) was obtained after 4½ months' treatment with gradually increasing doses of the drug.

4. The exo-erythrocytic parasites of P. gallinaceum formed in chicks infected with a paludrine-resistant strain are themselves resistant to the drug. It is not, however, considered probable that the development of resistance is due to the action of the drugs upon the exo-erythrocytic parasites, as the technique used was one which reduced their number to a minimum.

5. A strain of P. gallinaceum resistant to paludrine showed a normal sensitivity to mepacrine and pamaquin, but was resistant to 4430, the methyl homologue of paludrine.

6. Chicks carrying a latent infection of the normal strain of P. gallinaceum were immune to infection with the paludrine-resistant strain; and conversely chicks carrying a latent infection of the paludrine-resistant strain were immune to infection with the normal parasite.

7. A paludrine-resistant strain of P. gallinaceum retained its resistance to this drug after five cyclical passages through mosquitoes without intervening drug treatment.

Type
Research Article
Information
Parasitology , Volume 39 , Issue 1-2 , July 1948 , pp. 125 - 137
Copyright
Copyright © Cambridge University Press 1948

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