Development and Psychopathology

Emotion regulation in children and adolescents: Boundaries between normalcy and bipolar disorder

a1 National Institute of Mental Health

Article author query
dickstein dp   [PubMed][Google Scholar] 
leibenluft e   [PubMed][Google Scholar] 


Much controversy has surrounded the diagnosis of bipolar disorder (BD) in children and adolescents. However, recent work from an affective neuroscience perspective has advanced what is known about the boundaries of emotion regulation in BD compared to typically developing youth. In this article, we first briefly review the clinical issues that have contributed to this diagnostic controversy. Second, we discuss our phenotyping system, which can be used to guide neurobiological research designed to address these controversial issues. Third, we review what is known about the fundamentals of emotion regulation in human and nonhuman primate models. Fourth, we present recent data demonstrating how children and adolescents with BD differ from those without psychopathology on measures of emotion regulation. Taken as a whole, this work implicates a neural circuit encompassing the prefrontal cortex, amygdala, and striatum in the pathophysiology of pediatric BD. a

c1 Address correspondence and reprint requests to: Daniel P. Dickstein, National Institute of Mental Health, Pediatrics & Developmental Neuropsychiatry Branch, 9000 Rockville Pike, MSC 2670, Building 15K, Room 204, Bethesda, MD 20892-2670; E-mail:


a Both authors are affiliated with the Mood and Anxiety Disorders Program of the National Institute of Mental Health's Division of Intramural Research Programs (NIMH DIRP), which funded the work in its entirety. Dr. Dickstein is currently supported by a career development award (K22-MH 74945).