Epidemiology and Infection



A recurring outbreak of Shigella sonnei among traditionally observant Jewish children in New York City: the risks of daycare and household transmission


V. GARRETT a1, K. BORNSCHLEGEL a2, D. LANGE a1, V. REDDY a2, L. KORNSTEIN a2, J. KORNBLUM a2, A. AGASAN a2, M. HOEKSTRA a1, M. LAYTON a2 and J. SOBEL a1c1
a1 Centers for Disease Control and Prevention, Atlanta, GA, USA
a2 New York City Department of Health and Mental Hygiene, New York, NY, USA

Article author query
garrett v   [PubMed][Google Scholar] 
bornschlegel k   [PubMed][Google Scholar] 
lange d   [PubMed][Google Scholar] 
reddy v   [PubMed][Google Scholar] 
kornstein l   [PubMed][Google Scholar] 
kornblum j   [PubMed][Google Scholar] 
agasan a   [PubMed][Google Scholar] 
hoekstra m   [PubMed][Google Scholar] 
layton m   [PubMed][Google Scholar] 
sobel j   [PubMed][Google Scholar] 

Abstract

Dispersed community outbreaks of Shigella sonnei have occurred cyclically among traditionally observant Jews in the United States. In February 2000, we investigated a S. sonnei outbreak in one Jewish community in New York City. To determine risk factors for introduction of infection into households, we conducted a cohort study of households to compare risk factors for illness among primary subjects within households and age-matched well siblings. Isolates were subtyped by pulsed-field gel electrophoresis (PFGE). We used a random effects model to assess extra-household vs. intra-household transmission in households with multiple ill household members. Daycare or pre-school attendance [matched odds ratio (mOR) 16·1, P<0·001] and age <60 months (mOR 6·3, P<0·001) were independently associated with index subject illness. Outbreak isolates were closely related by PFGE analysis to the strain previously observed in Jewish community outbreaks. The random effects model strongly indicated that multiple illnesses in a single household are due to secondary transmission. Disease containment efforts should focus on reducing Shigella transmission in childcare settings and within homes.

(Accepted February 6 2006)
(Published Online April 20 2006)


Correspondence:
c1 Foodborne and Diarrheal Diseases Branch, CDC, MS-A38, Atlanta, GA 30333, USA. (Email: jsobel@cdc.gov)


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