Epidemiology and Infection



Characteristics of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus isolated from the nasopharynx of healthy children attending day-care centres in the Czech Republic


H. ŽEMLICKOVÁ a1c1, P. URBÁŠKOVÁ a1, V. ADÁMKOVÁ a1a2, J. MOTLOVÁ a1, V. LEBEDOVÁ a1 and B. PROCHÁZKA a1
a1 National Institute of Public Health, Šrobárova, Prague, Czech Republic
a2 Charles University, 3rd Faculty of Medicine, Ruská, Prague, Czech Republic

Article author query
zemlickova h   [PubMed][Google Scholar] 
urbaskova p   [PubMed][Google Scholar] 
adamkova v   [PubMed][Google Scholar] 
motlova j   [PubMed][Google Scholar] 
lebedova v   [PubMed][Google Scholar] 
prochazka b   [PubMed][Google Scholar] 

Abstract

Nasopharyngeal carriage of potential pathogens was studied in 425 healthy 3- to 6-year-old children attending 16 day-care centres (DCCs) in nine Czech cities during the winter 2004–2005. The overall carriage of pathogens was 62·8% (Streptococcus pneumoniae, 38·1%; Haemophilus influenzae, 24·9%; Moraxella catarrhalis, 22·1%; Staphylococcus aureus, 16%). An age-related downward trend was observed for colonization with respiratory pathogens in contrast to Staph. aureus whose carriage was significantly higher among older children. The following serotypes of colonizing S. pneumoniae were the most predominant: 23F (20·6%), 6A (15·1%), 6B (12·7%), 18C (7·8%), 15B and 19F (6% each). The majority (94·3%) of H. influenzae isolates were non-typable; among capsulated isolates, serotype b was not found. Decreased susceptibility to penicillin was determined in 3% of pneumococci; 4·6% of H. influenzae strains and 85·1% of M. catarrhalis strains produced β-lactamase. As for non-β-lactam antibiotics, pneumococci resistant to trimethoprim–sulphamethoxazole were the most common (15·7%) among the attendees.

(Accepted February 2 2006)
(Published Online May 10 2006)


Correspondence:
c1 National Institute of Public Health, Šrobárova 48, 100 42 Prague 10, Czech Republic. (Email: hzemlickova@szu.cz)


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