Parasitology



Genotyping of human cystic echinococcosis in Xinjiang, PR China


J. M. BART a1a2c1, M. ABDUKADER a1, Y. L. ZHANG a1, R. Y. LIN a1, Y. H. WANG a1, M. NAKAO a3, A. ITO a3, P. S. CRAIG a4, R. PIARROUX a2, D. A. VUITTON a2 and H. WEN a1
a1 First Teaching Hospital, Xinjiang Medical University, Urumqi 830000, PR China
a2 SERF Unit, Faculty of Medicine, University of Franche-Comté, Besancon 25000, France
a3 Department of Parasitology, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
a4 Cestode Zoonoses Research Group, Biomedical Sciences Research Institute and School of Environment and Life Sciences, University of Salford, Greater Manchester M54WT, UK

Article author query
bart jm   [PubMed][Google Scholar] 
abdukader m   [PubMed][Google Scholar] 
zhang yl   [PubMed][Google Scholar] 
lin ry   [PubMed][Google Scholar] 
wang yh   [PubMed][Google Scholar] 
nakao m   [PubMed][Google Scholar] 
ito a   [PubMed][Google Scholar] 
craig ps   [PubMed][Google Scholar] 
piarroux r   [PubMed][Google Scholar] 
vuitton da   [PubMed][Google Scholar] 
wen h   [PubMed][Google Scholar] 

Abstract

The Xinjiang Uygur Autonomous Region, multi-ethnic province in northwestern China, is one of the most important foci of human cystic echinococcosis (CE) in the world. Two Echinococcus granulosus genotypes (G1 and G6) are known to infect the intermediate hosts in this area but, to date, the source of the human infection remains unclear. The current study aimed to genetically analyse 67 hydatid cysts removed from 47 CE patients for which epidemiological, clinical and serological data were also recorded. Mitochondrial cox 1 gene sequencing suggested that the E. granulosus G1 genotype is the major source of infection (45/47 CE patients). Nevertheless, for the first time in China, 2 patients were found with hydatid cysts of the G6 genotype. In addition, 45 E. granulosus gravid tapeworms, isolated from 13 dogs, were genotyped. The majority of adult worms (42/45) exhibited the G1 genotype, whereas 3 adult tapeworms with the G6 genotype were found in one dog, that also harboured E. granulosus tapeworms of the G1 genotype. This sympatric occurrence of G1 and G6 genotypes of E. granulosus, not only in the same area but also in the same definitive host, raises the interesting question of putative genetic recombination between these E. granulosus genotypes.

(Received March 7 2006)
(Revised May 10 2006)
(Revised May 23 2006)
(Accepted May 23 2006)
(Published Online July 12 2006)


Key Words: Echinococcus granulosus; genotype; Xinjiang; human; dog.

Correspondence:
c1 19 rue Ambroise Paré, University of Franche-Comté, 25000 Besançon, France. Tel: 00 33 3 63 08 22 36. E-mail: jmbart2000@yahoo.fr


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