The International Journal of Neuropsychopharmacology



Increased mitochondrial complex I activity in platelets of schizophrenic patients


Dorit Ben-Shachar a1c1, Rosa Zuk a1, Haifa Gazawi a1, Alon Reshef a1, Ala Sheinkman a2 and Ehud Klein a1
a1 Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel
a2 Mental Health Center, Tirat Hacarmel, Haifa, Israel

Abstract

It is believed that dopamine and alterations of energy metabolism in cortical and subcortical structures are involved in the pathophysiology of schizophrenia. Recently, we and others have shown that dopamine may affect energy metabolism by interacting with mitochondrial complex I activity in rats both in vivo and in vitro. In this study activity of complexes I and IV was assessed in mitochondria isolated from blood platelet of schizophrenic patients and compared to patients with affective disorders and healthy control subjects. Seventy-seven in-patients who met DSM-IV criteria for schizophrenia (in acute exacerbation), bipolar disorder depressed type (BP), or recurrent major depressive disorder (MDD) and 24 control subjects participated in the study. A highly significant increase (240%, p < 0.001) in complex I activity but not in complex IV, was detected in medicated and unmedicated schizophrenic patients compared to controls. No such change was observed in patients with affective disorders. The data demonstrate a specific and selective, alteration in platelet complex I activity in schizophrenic patients, which is not related to medication. If this abnormality in platelet mitochondria reflects brain alterations, it may further support the relevance of alterations in energy metabolism to the pathophysiology of schizophrenia. Finally in the lack of any clinically relevant biological marker for schizophrenia, complex I activity in platelets might become a useful peripheral marker for this disorder.

(Received March 15 1999)
(Reviewed May 6 1999)
(Revised June 27 1999)
(Accepted June 30 1999)


Key Words: Schizophrenia; mitochondria; complex I; cytochrome c oxidase; platelets.

Correspondence:
c1 Address for correspondence: Dr D. Ben-Shachar, Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B. Rappaport Faculty of Medicine, Technion ITT, PO Box 9649, Haifa 31096, Israel. Tel.: 972–4-8295224 Fax: 972-4-543050 E-mail: shachar@tx.technion.ac.il


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