Psychological Medicine

Research Article

Erythrocyte membrane cation carrier in depressive illness1

G. J. Naylora1 c1, D. A. T. Dicka1, E. G. Dicka1, D. Le Poidevina1 p1 and S. F. Whytea1

a1 From the Departments of Psychiatry and Anatomy, University of Dundee


Erythrocyte sodium concentration, potassium concentration, Na-K ATPase activity, and ouabain sensitive potassium influx were determined in female inpatients suffering from a depressive illness. In most patients the biochemical values were also determined shortly before the patient's discharge from hospital. The Na-K ATPase and the ouabain sensitive potassium influx increased significantly with improvement in the depressive mood rating.


c1 Address for correspondence: Dr. G. J. Naylor, Department of Psychiatry, University of Dundee, Dundee, DD1 4HN.

p1 Present address: Royal Cornhill Hospital, 26 Cornhill Road, Aberdeen, AB9 2ZH.


1 These studies were supported by a grant to G.J.N. and D.A.T.D. by the Scottish Hospitals Endowment Research Trust.