Psychological Medicine

Preliminary communication

A controlled evaluation of lithium prophylaxis in affective disorders

R. L. Cundalla11, P. W. Brooksa1 and L. G. Murraya12

a1 From the M.R.C. Brain Metabolism Unit3, Royal Edinburgh Hospital, Edinburgh


In a double-blind crossover trial lithium carbonate was found to be significantly superior to placebo in the prophylaxis of manic-depressive (bipolar) psychosis. A striking feature was the high incidence of manic or hypomanic attacks in patients who relapsed on placebo. Patients participated in the trial with their full knowledge and consent.


1 Wellcome Research Fellowship in Clinical Pharmacology. Present address: The State Hospital, Carstairs Junction, Lanark.

2 Requests for reprints to Dr. L. G. Murray.

3 Director: Dr. G. W. Ashcroft.