Psychological Medicine

Preliminary communication

A controlled evaluation of lithium prophylaxis in affective disorders

R. L. Cundalla11, P. W. Brooksa1 and L. G. Murraya12

a1 From the M.R.C. Brain Metabolism Unit3, Royal Edinburgh Hospital, Edinburgh

Abstract

In a double-blind crossover trial lithium carbonate was found to be significantly superior to placebo in the prophylaxis of manic-depressive (bipolar) psychosis. A striking feature was the high incidence of manic or hypomanic attacks in patients who relapsed on placebo. Patients participated in the trial with their full knowledge and consent.

Footnotes

1 Wellcome Research Fellowship in Clinical Pharmacology. Present address: The State Hospital, Carstairs Junction, Lanark.

2 Requests for reprints to Dr. L. G. Murray.

3 Director: Dr. G. W. Ashcroft.

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