a1 From the M.R.C. Brain Metabolism Unit3, Royal Edinburgh Hospital, Edinburgh
In a double-blind crossover trial lithium carbonate was found to be significantly superior to placebo in the prophylaxis of manic-depressive (bipolar) psychosis. A striking feature was the high incidence of manic or hypomanic attacks in patients who relapsed on placebo. Patients participated in the trial with their full knowledge and consent.
1 Wellcome Research Fellowship in Clinical Pharmacology. Present address: The State Hospital, Carstairs Junction, Lanark.
2 Requests for reprints to Dr. L. G. Murray.
3 Director: Dr. G. W. Ashcroft.