Psychological Medicine

Research Article

The pathophysiology of extrapyramidal side-effects of neuroleptic drugs

C. D. Marsdena1 c1 and P. Jennera1

a1 University Department of Neurology, Institute of Psychiatry, and King's College Hospital Medical School, London

Abstract

The mechanisms responsible for the production of major extrapyramidal side-effects (parkinsonism, akathisia, acute dystonic reactions, chronic tardive dyskinesias) are reviewed in the light of the complex effects of these drugs on cerebral dopamine systems.

Correspondence:

c1 Address for correspondence: Professor C. D. Marsden, University Department of Neurology, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF.

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