Journal of Helminthology

Research Article

Comparative efficacy of standard antihookworm drugs against various test nematodes

Anuradha Misraa1, P. K. S. Visena1 and J. C. Katiyara1

a1 Division of Parasitology, Central Drug Research Institute, Lucknow-226001, India

Abstract

The chemotherapeutic responses of three test nematodes, Nippostrongylus brasilietxsis, Nematospiroidesdubius and Ancylostoma ceylanicum to standard antihookworm drugs were assessed in order to select asuitable host-parasite system for the primary screening of potential antihookworm compounds. N. dubiusbehaved inconsistently and, with some infections, required more drug to achieve 100% clearance. Nippostrongylus brasiliensis was found to be sensitive to thiabendazole, tetramisole and levamisole but the broad spectrum anthclmintic mebendazole was ineffective. A. ceylanicum was very sensitive to mebendazole, sensitive to tetramisole and levamisole and refractory to thiabendazole. In vitro, none of the compounds had any lethal effect against any of the nematodes, except mebendazole against A. ceylanicum.

A. ceylanicum does occur in man and its chemotherapeutic reactions are similar to those of target hookworm infections of economic importance. As such, although not equally sensitive to standard anthelmintics, it is recommended for routine primary screening.