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Cognitive dysfunction in schizophrenia followed up over 5 years, and its longitudinal relationship to the emergence of tardive dyskinesia

Published online by Cambridge University Press:  09 July 2009

John L. Waddington*
Affiliation:
Royal College of Surgeons in Ireland, Dublin; St Davnet's Hospital, Monaghan; Dublin Institute of Technology, Ireland
Hanafy A. Youssef
Affiliation:
Royal College of Surgeons in Ireland, Dublin; St Davnet's Hospital, Monaghan; Dublin Institute of Technology, Ireland
Anthony Kinsella
Affiliation:
Royal College of Surgeons in Ireland, Dublin; St Davnet's Hospital, Monaghan; Dublin Institute of Technology, Ireland
*
1Address for correspondence: Dr John L. Waddington, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland.

Synopsis

In this study, 51 chronic schizophrenic in-patients were evaluated for a range of demographic, clinical and medication variables, and followed up over five years. There was no significant overall change in cognitive function in this patient group as a whole, suggesting the absence of active disease at this stage of the illness. The only correlate of individual instances of cognitive deterioration over the study period was the emergence of new cases of tardive buccal-lingual-masticatory but not of limb-trunkal dyskinesia, and the greater severity of such movement disorder. A positive family history was also identified prospectively as a predictor of the emergence of tardive dyskinesia in chronic schizophrenia.

Type
Orginal Articles
Copyright
Copyright © Cambridge University Press 1990

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References

REFERENCES

Bartels, M., Mann, K. & Friedrich, W. (1985). Tardive dyskinesia: marked predominance of nongenetic schizophrenia. Biological Psychiatry 20, 101103.CrossRefGoogle ScholarPubMed
Buhrich, N., Crow, T. J., Johnstone, E. C. & Owens, D. G. C. (1988). Age disorientation in chronic schizophrenia is not associated with pre-morbid intellectual impairment or past physical treatment. British Journal of Psychiatry 152, 466469.CrossRefGoogle ScholarPubMed
Davis, J. M. (1976). Comparative doses and costs of antipsychotic medication. Archives of General Psychiatry 33, 858861.CrossRefGoogle ScholarPubMed
Edwards, H. (1970). The significance of brain damage in persistent oral dyskinesia. British Journal of Psychiatry 116, 271275.CrossRefGoogle ScholarPubMed
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972). Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry 26, 5763.CrossRefGoogle ScholarPubMed
Fleiss, J. L., Williams, J. B. W. & Dubro, A. F. (1986). Logistic regression analysis of psychiatric data. Journal of Psychiatric Research 20, 195209.CrossRefGoogle ScholarPubMed
Glazer, W. M., Morgenstern, H., Niedzwiecki, D. & Hughes, J. (1988). Heterogeneity of tardive dyskinesia: a multivariate analysis. British Journal of Psychiatry 152, 253259.CrossRefGoogle ScholarPubMed
Goldberg, E. (1985). Akinesia, tardive dysmentia, and frontal lobe disorder in schizophrenia. Schizophrenia Bulletin 11, 255263.CrossRefGoogle ScholarPubMed
Goldberg, T. E. & Weinberger, D. R. (1986). Methodological issues in the neuropsychological approach to schizophrenia. In Handbook of Schizophrenia (ed. Nasrallah, H. A. and Weinberger, D. R.), pp. 141156. Elsevier: Amsterdam.Google Scholar
Goldberg, T. E., Karson, C. N., Leleszi, J. P. & Weinberger, D. R. (1988 a). Intellectual impairment in adolescent psychosis. Schizophrenia Research 1, 261266.CrossRefGoogle ScholarPubMed
Goldberg, T. E., Kleinman, J. E., Daniel, D. G., Myslobodsky, M. S., Ragland, J. D. & Weinberger, D. R. (1988 b). Dementia praecox revisited: age disorientation, mental status and ventricular enlargement. British Journal of Psychiatry 153, 187190.CrossRefGoogle ScholarPubMed
Johnstone, E. C., Crow, T. J., Frith, C. D., Husband, J. & Kreel, L. (1976). Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet i, 924926.CrossRefGoogle Scholar
Karson, C. N., Jeste, D. V., LeWitt, P. A. & Wyatt, R. J. (1983). A comparison of two iatrogenic dyskinesias. American Journal of Psychiatry 140, 15041506.Google ScholarPubMed
Kidger, T., Barnes, T. R. E., Trauer, T. & Taylor, P. J. (1980). Subsyndromes of tardive dyskinesia. Psychological Medicine 10, 513520.CrossRefGoogle ScholarPubMed
Ko, G. N., Zhang, L. D., Yan, W. W., Zhang, M. D., Buchner, D., Xia, Z. Y., Wyatt, R. J. & Jeste, D. V. (1989). The Shanghai 800: prevalence of tardive dyskinesia in a Chinese psychiatric hospital. American Journal of Psychiatry 146, 387389.Google Scholar
Lewis, S. W. (1989). Congenital risk factors for schizophrenia. Psychological Medicine 19, 513.CrossRefGoogle ScholarPubMed
Murray, R. M. & Lewis, S. W. (1987). Is schizophrenia a neurodevelopmental disorder? British Medical Journal 295, 681682.CrossRefGoogle ScholarPubMed
Myslobodsky, M. S. (1986). Anosognosia in tardive dyskinesia: ‘tardive dysmentia’ or ‘tardive dementia’? Schizophrenia Bulletin 12, 119.CrossRefGoogle ScholarPubMed
National Institute of Mental Health (1976). Abnormal involuntary movement scale. In Early Clinical Drug Evaluation Unit Assessment Manual (ed. Guy, W.), pp. 534537. US Dept of Health and Human Services: Rockville.Google Scholar
Waddington, J. L. (1989). Schizophrenia, affective psychoses and other disorders treated with neuroleptic drugs: the enigma of tardive dyskinesia, its neurobiological determinants, and the ‘conflict of paradigms’. International Review of Neurohiology 31, 297353.CrossRefGoogle ScholarPubMed
Waddington, J. L. & Youssef, H. A. (1986 a). Late onset involuntary movements in chronic schizophrenia: relationship of tardive dyskinesia to intellectual impairment and negative symptoms. British Journal of Psychiatry 149, 616620.CrossRefGoogle ScholarPubMed
Waddington, J. L. & Youssef, H. A. (1986 b). An unusual cluster of tardive dyskinesia in schizophrenia: association with cognitive dysfunction and negative symptoms. American Journal of Psychiatry 143, 11621165.Google ScholarPubMed
Waddington, J. L. & Youssef, H. A. (1988 a). Tardive dyskinesia in bipolar affective disorder: aging, cognitive dysfunction, course of illness and exposure to neuroleptics and lithium. American Journal of Psychiatry 145, 613616.Google ScholarPubMed
Waddington, J. L. & Youssef, H. A. (1988 b). The expression of schizophrenia, affective disorder and vulnerability to tardive dyskinesia in an extensive pedigree. British Journal of Psychiatry 153, 376381.CrossRefGoogle Scholar
Waddington, J. L., Youssef, H. A., Dolphin, C. & Kinsella, A. (1987). Cognitive dysfunction, negative symptoms and tardive dyskinesia in schizophrenia: their association in relation to topography of involuntary movements and criterion of their abnormality. Archives of General Psychiatry 44, 907912.CrossRefGoogle ScholarPubMed
Waddington, J. L., O'Callaghan, E. & Larkin, C. (1988 a). Premorbid neuropathology in schizophrenia. Lancet ii, 959960.CrossRefGoogle Scholar
Waddington, J. L., O'Callaghan, E. & Larkin, C. (1988 b). Vulnerability to involuntary movements in relation to family history of schizophrenia and obstetric complications. Schizophrenia Research 1, 233234.Google Scholar
Wegner, J. T., Kane, J. M., Weinhold, P., Woerner, M., Kinon, B. & Lieberman, J. (1985 a). Cognitive impairment in tardive dyskinesia. Psychiatry Research 16, 331337.CrossRefGoogle ScholarPubMed
Wegner, J. T., Catalano, R., Gibralter, J. & Kane, J. M. (1985 b). Schizophrenics with tardive dyskinesia: neuropsychological deficit and family psychopathology. Archives of General Psychiatry 42, 860865.CrossRefGoogle ScholarPubMed
Weinberger, D. R (1987). Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry 44, 660669.CrossRefGoogle ScholarPubMed
Weinhold, P., Wegner, J. T., & Kane, J. M. (1981). Familial occurrence of tardive dyskinesia. Journal of Clinical Psychiatry 42, 165166.Google ScholarPubMed
Yassa, R. & Ananth, J. (1981). Familial tardive dyskinesia. American Journal of Psychiatry 138, 16181619.Google ScholarPubMed