Psychological Medicine

Orginal Articles

Psychosis associated with demonstrable brain disease

Anthony Feinsteina1 c1 and Maria A. Rona1

a1 National Hospital for Nervous Diseases, London


Sixty-five psychotic patients with unequivocal evidence of brain pathology and a variety of neurological disorders were assessed with respect to phenomenology and outcome. No relationship was found between site of brain pathology and type of psychotic disorder. A majority of patients had a syndrome indistinguishable from schizophrenia without coarse brain involvement and shared similar variables predicting outcome of psychosis, thus raising important issues concerning their nosological status.


c1 Address for correspondence: Dr Anthony Feinstein, National Hospital for Nervous Diseases, Queen Square, London WC1N 3BG.