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New DNA markers with increased informativeness show diminished support for a chromosome 5q11–13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families

Published online by Cambridge University Press:  01 May 1999

G. KALSI
Affiliation:
Molecular Psychiatry Laboratory, Windeyer Institute for Medical Research, Department of Psychiatry and Behavioural Sciences, Windeyer Building, University College London Medical School, Cleveland Street, University of London, London W1P 7PN
B. MANKOO
Affiliation:
Molecular Psychiatry Laboratory, Windeyer Institute for Medical Research, Department of Psychiatry and Behavioural Sciences, Windeyer Building, University College London Medical School, Cleveland Street, University of London, London W1P 7PN
D. CURTIS
Affiliation:
Joint Academic Department of Psychological Medicine, St Bartholomew's and Royal London School of Medicine and Dentistry, 3rd Floor Alexander Wing, Turner Street, London E1 1BB
R. SHERRINGTON
Affiliation:
Molecular Psychiatry Laboratory, Windeyer Institute for Medical Research, Department of Psychiatry and Behavioural Sciences, Windeyer Building, University College London Medical School, Cleveland Street, University of London, London W1P 7PN
G. MELMER
Affiliation:
Molecular Psychiatry Laboratory, Windeyer Institute for Medical Research, Department of Psychiatry and Behavioural Sciences, Windeyer Building, University College London Medical School, Cleveland Street, University of London, London W1P 7PN
J. BRYNJOLFSSON
Affiliation:
Molecular Psychiatry Laboratory, Windeyer Institute for Medical Research, Department of Psychiatry and Behavioural Sciences, Windeyer Building, University College London Medical School, Cleveland Street, University of London, London W1P 7PN
T. SIGMUNDSSON
Affiliation:
Department of Psychiatry, University of Iceland, General Hospital, Reykjavik 108, Iceland
T. READ
Affiliation:
Molecular Psychiatry Laboratory, Windeyer Institute for Medical Research, Department of Psychiatry and Behavioural Sciences, Windeyer Building, University College London Medical School, Cleveland Street, University of London, London W1P 7PN
P. MURPHY
Affiliation:
Molecular Psychiatry Laboratory, Windeyer Institute for Medical Research, Department of Psychiatry and Behavioural Sciences, Windeyer Building, University College London Medical School, Cleveland Street, University of London, London W1P 7PN
H. PETURSSON
Affiliation:
Department of Psychiatry, University of Iceland, General Hospital, Reykjavik 108, Iceland
H. GURLING
Affiliation:
Molecular Psychiatry Laboratory, Windeyer Institute for Medical Research, Department of Psychiatry and Behavioural Sciences, Windeyer Building, University College London Medical School, Cleveland Street, University of London, London W1P 7PN
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Abstract

Genetic linkage of schizophrenia to markers at 5q11.2–13.3 had been reported previously in five Icelandic and two British families, but attempts at replication in independent samples have been unsuccessful. We report here an update on the diagnoses and results of linkage analyses using newer highly polymorphic microsatellite markers at or near the loci D5S76 and D5S39 in the original sample of pedigrees and in two new family samples from Iceland and from Britain. The new results show a reduction in evidence for linkage in the original sample and evidence against linkage in the two new family samples. Although it is possible that a rare locus is present, perhaps in the region 5p14.1–13.1 rather than 5q11.2–13.3, it appears most likely that the original positive lod scores represent an exaggeration of the ‘true’ lod scores due to random effects and that the small lod scores we now obtain could have arisen by chance.

Type
Research Article
Copyright
© University College London 1999

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