Parasitology


Programmed cell death and the protozoan parasite

Programmed cell death in African trypanosomes


S. C. WELBURN a1c1, E. MACLEOD a1, K. FIGARELLA a2 and M. DUZENSKO a2
a1 Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, EH25 9RG
a2 Department of Biochemistry, University of Tubingen, Hoppe-Seyler-Str. 4, 72076 Tubingen, Germany

Article author query
welburn sc   [PubMed][Google Scholar] 
macleod e   [PubMed][Google Scholar] 
figarella k   [PubMed][Google Scholar] 
duzensko m   [PubMed][Google Scholar] 

Abstract

Until recently it had generally been assumed that apoptosis and other forms of programmed cell death evolved during evolution of the metazoans to regulate growth and development in these multicellular organisms. However, recent research is adding strength to the original phenotypic observations described almost a decade ago which indicated that some parasitic protozoa may have evolved a cell death pathway analogous to the process described as apoptosis in metazoa. Here we explore the implications of a programmed cell death pathway in the African tsetse-transmitted trypanosomes.


Key Words: Apoptosis; programmed cell death; Trypanosoma brucei; trypanosomatids.

Correspondence:
c1 Email: sue.welburn@ed.ac.uk


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