Psychological Medicine

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Psychological Medicine (1992), 22:101-115 Cambridge University Press
Copyright © Cambridge University Press 1992

Original Articles

Memory impairment in schizophrenia: its extent, affiliations and neuropsychological character

D. Tamlyna1, P. J. McKennaa1 c1, A. M. Mortimera1, C. E. Lunda1, S. Hammonda1 and A. D. Baddeleya1

a1 Fulbourn Hospital and MRC Applied Psychology Unit, Cambridge; University Department of Psychiatry and High Royds Hospital, Leeds; St Luke's Hospital, Huddersfield
Article author query
tamlyn d [PubMed]  [Google Scholar]
mckenna pj [PubMed]  [Google Scholar]
mortimer am [PubMed]  [Google Scholar]
lund ce [PubMed]  [Google Scholar]
hammond s [PubMed]  [Google Scholar]
baddeley ad [PubMed]  [Google Scholar]


In a sample of 60 schizophrenic patients encompassing all grades of severity and chronicity memory impairment was found to be prevalent, often substantial, and disproportionate to the overall level of intellectual impairment. The deficits were not easily attributable to poor cooperation, attention or motivation; nor were they related to neuroleptic or anticholinergic medication. Memory impairment was significantly associated with severity and chronicity of illness and also with negative symptoms and formal thought disorder. There was evidence from the sample as a whole, and from a more detailed examination of five patients with relatively isolated deficits, that schizophrenic memory impairment conformed to the pattern seen in the classical amnesic syndrome. Additionally, there was preliminary evidence for a marked deficit in semantic memory.


c1 Address for correspondence: Dr P. J. McKenna, Fulbourn Hospital, Cambridge CBI 5EF.