Psychological Medicine

Original Articles

Subjective response to neuroleptics and outcome in schizophrenia: a re-examination comparing two measures

T. P. Hogana1 c1 and A. G. Awada1

a1 Queen Street Mental Health Centre and the Department of Psychiatry, University of Toronto, Canada


The schizophrenic patient's early psychological response to neuroleptic treatment has been demonstrated to be a significant predictor of treatment response. The validity of the construct of subjective response is evaluated by comparison of two measures. Fifty-five recently admitted and unmedicated schizophrenic patients were randomly allocated to chlorpromazine or haloperidol. Subjective responses at 24 and 48 hours as assessed by two different scales, the Van Putten & May scale and the self-administered Drug Attitude Inventory, were strongly correlated with outcome at three weeks. Early emergence of extrapyramidal symptoms was not related to subjective response, but dysphoric patients had a greater incidence of EPS by the end of treatment than did non-dysphoric patients. The two measures showed high concordance in identification of early drug dysphoria.


c1 Address for correspondence: Mr T. P. Hogan, Psychology and Biometrics Section, Schizophrenia Research Program, Queen Street Mental Health Centre, 1001 Queen Street West, Toronto, Canada, M6J 1H4.