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Volumetric MRI measurements in bipolars compared with schizophrenics and healthy controls

Published online by Cambridge University Press:  09 July 2009

I. Harvey ,
R. Persaud ,
M. A. Ron ,
G. Baker  and
R. M. Murray
I. Harvey
Affiliation:
Institute of Neurology; Institute of Psychiatry, London
R. Persaud
Affiliation:
Institute of Neurology; Institute of Psychiatry, London
M. A. Ron*
Affiliation:
Institute of Neurology; Institute of Psychiatry, London
G. Baker
Affiliation:
Institute of Neurology; Institute of Psychiatry, London
R. M. Murray
Affiliation:
Institute of Neurology; Institute of Psychiatry, London
*
1Address for correspondence: Professor Maria A. Ron, Institute of Neurology, Queen Square, London WC1N 3BG
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Synopsis

Twenty-six patients with RDC bipolar disorder were compared with a previously reported group of 48 RDC schizophrenics and 34 healthy controls, using volumetric MRI measurements of cerebral, cortical and sulcal volumes. The bipolar group appeared no different from the controls, and both of these groups had significantly larger cerebral and cortical volumes than the schizophrenics. Our previous report of a significantly reduced cortical volume in the schizophrenic group, with a corresponding increase in the volume of sulcal fluid is, therefore, not a generalized feature of psychotic illness but may be more specific to schizophrenia.

Type
Original Articles
Information
Psychological Medicine , Volume 24 , Issue 3 , August 1994 , pp. 689 - 699
Copyright
Copyright © Cambridge University Press 1994

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