Psychological Medicine

Research Article

A review of the biochemical and neuropharmacological actions of lithium

Andrew J. Wooda1 c1 and Guy M. Goodwina1 p1

a1 MRC Unit and University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford

Abstract

The pharmacological actions central to the therapeutic effects of lithium have not yet been established, despite almost 40 years of clinical use and scientific investigation. We review the biochemical and neuropharmacological data relating to this problem and attempt to identify profitable areas for further research.

Correspondence:

c1 Address for correspondence: Dr A. J. Wood, MRC Clinical Pharmacology Unit & University Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE.

p1 Present address: MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh EH10 5HF.

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