Psychological Medicine

Research Article

Schizophrenic syndromes, cognitive performance and neurological dysfunction

Peter F. Liddlea1 c1

a1 Department of Psychiatry, University of Oxford


In a sample of chronic schizophrenic patients, a group of symptoms which included poverty of speech and lack of spontaneous movement was found to be associated with poor performance in tests of conceptual thinking, object naming and long-term memory, and also with cortical neurological signs. A second group of symptoms which included formal thought disorder and inappropriate affect was associated with poor performance in tests of concentration, immediate recall and word learning, and with cortical neurological signs. The findings suggest that these two syndromes are associated with dysfunction at two different sites within the frontal lobes. A third group of symptoms, comprising various delusions and hallucinations, was associated with poor figure-ground perception, and might reflect temporal lobe dysfunction.


c1 Address for correspondence: Dr P. F. Liddle, Charing Cross and Westminster Medical School, Academic Unit, Horton Hospital, Long Grove Road, Epsom, Surrey KT9 8PZ.