Psychological Medicine

Research Article

Dextroamphetamine-induced arousal in human subjects as a model for mania

D. Jacobsa1 c1 and T. Silverstonea1

a1 Academic Unit of Human Psychopharmacology, Medical College of St Bartholmew's and the London Hospitals, German Hospital, London


Because of the practical difficulties which arise in studying manic patients, a reproducible model for mania using human subjects would be a valuable adjunct to research in this condition. Dextroamphetamine, given as a single oral 20 mg dose, fulfils the criteria for such a model in that there are very close similarities between the changes which occur after dextroamphetamine and those which have been observed in mania in terms of subjective experience, physiological and endocrine changes, and response to pharmacological agents.


c1 Address for correspondence: Dr D. Jacobs, Department of Psychiatry and Behavioural Science, Sir Charles Gairdner Hospital, The Queen Elizabeth II Medical Centre, Verdun Street, Nedlands, Western Australia 6009.