Psychological Medicine

Research Article

The role of oestrogen replacement in the climacteric syndrome

Rudi Bortha1 c1, Ronald C. Stricklera1, Anthony Cecuttia1, Brian A. Cooksona1, John A. Harpera1, Robert Potvina1, Paul Riffela1, V. James Sorbaraa1 and C. Allan Woolevera1

a1 From the Departments of Obstetrics and Gynaecology and of Psychology, St Michael's Hospital, University of Toronto, Canada


Using a double-blind placebo-controlled cross-over design, the effect of equine conjugated oestrogens tablets (Premarin®) was studied in 20 women with the climacteric syndrome followed during 15 months. Sixteen women were equally improved on placebo and oestrogen. Only 2 patients had an improved sense of well-being on oestrogen and not on placebo. The psychological diagnosis was unrelated to the subjective response to oestrogen or placebo. Performance in psychological tests administered before and during treatment periods was not changed by oestrogen or placebo.


c1 1Address for correspondence: Dr Rudi Borth, Department of Obstetrics and Gynaecology, St Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8.