Epidemiology and Infection

Research Article

Genetic relationships between southern African SAT-2 isolates of foot-and-mouth-disease virus

W. Voslooa1, N. J. Knowlesa2 and G. R. Thomsona1

a1 Foot-and-Mouth Disease Laboratory, Private Bag X5, Onderstepoort 0110, South Africa

a2 AFRC Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Working, Surrey, GU24 ONF, England


Sequencing of part of the 1D gene of foot-and-mouth disease virus was used to determine the relationships between SAT-2 viruses isolated from outbreaks which occurred in cattle in Zimbabwe and Namibia and in impala in South Africa between 1979 and 1989. The results demonstrated that the outbreaks in different countries were unrelated. Surprisingly close relationships were shown between all SAT-2 viruses isolated from cattle in Zimbabwe since 1983 but the two major epizootics which occurred in 1989 were caused by viruses which were clearly different. Conversely, two apparently unrelated outbreaks in impala in South Africa were caused by viruses which could not be distinguished.

(Accepted June 03 1992)