Hostname: page-component-6b989bf9dc-zrclq Total loading time: 0 Render date: 2024-04-14T22:30:06.682Z Has data issue: false hasContentIssue false

Prevalence of serum IgG antibodies to Puumala virus (haemorrhagic fever with renal syndrome) in Northern Sweden

Published online by Cambridge University Press:  15 May 2009

C. Ahlm*
Affiliation:
Department of Infectious DiseasesUniversity of Umeå, Umeå, Sweden Department of VirologyUniversity of Umeå, Umeå, Sweden
M. Linderholm*
Affiliation:
Department of Infectious DiseasesUniversity of Umeå, Umeå, Sweden Department of VirologyUniversity of Umeå, Umeå, Sweden
P. Juto
Affiliation:
Department of VirologyUniversity of Umeå, Umeå, Sweden
B. Stegmayr
Affiliation:
Department of Internal Medicine, University of Umeå, Umeå, Sweden
B. Settergren
Affiliation:
Department of Infectious DiseasesUniversity of Umeå, Umeå, Sweden
*
* Address for correspondence and reprint requests: Dr Clas Ahlm, Department of Infectious Diseases. University of Umeå, S-901 85 Umeå, Sweden.
* Address for correspondence and reprint requests: Dr Clas Ahlm, Department of Infectious Diseases. University of Umeå, S-901 85 Umeå, Sweden.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A stratified and randomly-selected population sample was identified in 1990 in order to study the seroprevalence of nephropathia epidemica (haemorrhagic fever with renal syndrome) in Northern Sweden. Sera from 1538 subjects (750 men, 788 women), 25—64 years of age, were analysed for the presence of Puumala virus (PUV) specific-IgG by the indirect immunofluorescence antibody test. Specific IgG was detected in sera from 83 subjects (5·4%). Men and women had similar seroprevalence rates. The highest seroprevalences were found in subjects 55 years or older (8·0%) and among farmers and forestry workers (15·9%). The geographic distribution of seropositive individuals was uneven and there were significantly more seropositive persons in rural than in urban areas (P < 0·05).

Type
Research Article
Copyright
Copyright © Cambridge University Press 1994

References

REFERENCES

1.Gajdusek, DC. Virus hemorrhagic fevers – special reference to hemorrhagic fever with renal syndrome (epidemic hemorrhagic fever). J Pediatr 1962; 60: 841–57.CrossRefGoogle ScholarPubMed
2.Lee, HW, Lee, PW, Baek, LJ, Chu, YK. Geographical distribution of hemorrhagic fever with renal syndrome and hantaviruses. Arch Virol 1990; (suppl 1): 518.Google Scholar
3.Settergren, B. Nephropathia epidemica (Hemorrhagic fever with renal syndrome) in Scandinavia. Rev Infect Dis 1991; 13: 736–44.CrossRefGoogle ScholarPubMed
4.Niklasson, B, LeDuc, J. Isolation of the nephropathia epidemica agent in Sweden. Lancet 1984; i: 1012–13.CrossRefGoogle Scholar
5.Niklasson, B, LeDuc, J. Epidemiology of nephropathia epidemica in Sweden. J Infect Dis 1987; 155: 269–76.CrossRefGoogle ScholarPubMed
6.Settergren, B, Juto, P, Wadell, G, Trollfors, B, Norrby, SR. Incidence and geographic distribution of serologically verified cases of nephropathia epidemica in Sweden. Am J Epidemiol 1988; 127: 801–7.CrossRefGoogle ScholarPubMed
7.Niklasson, B, Nyman, L, Linde, A, Grandien, M, Dalrymple, J. An epidemiological survey of nephropathia epidemica in Sweden. Scand J Infect Dis 1983; 15: 239–45.CrossRefGoogle ScholarPubMed
8.Niklasson, B, LeDuc, J, Nyström, K, Nyman, L. Nephropathia epidemica: incidence of clinical cases and antibody prevalence in an endemic area of Sweden. Epidemiol Infect 1987; 99: 559–62.CrossRefGoogle Scholar
9.WHO MONICA Project Principle Investigators: The World Health Organization MONICA Project (Monitoring trends and determinants in cardiovascular disease): a major international collaboration. J Clin Epidemiol 1988; 41: 105–14.CrossRefGoogle Scholar
10. Occupation in Population and Housing Census 1985 (FoB 85) according to Nordic standard classification and Swedish socio-economic classification. Stockholm: Statistics Sweden, 1989. Reports on Statistical Co-ordination 1989: 5.Google Scholar
11.Localities 1990. Population and area in urban and rural areas. Revised figures. Stockholm: Statistics Sweden, 1992. Statistical reports Na 38 SM 9201.Google Scholar
12.Sommer, A-I, Traavik, T, Mehl, R, Berdal, BP, Dalrymple, J. Hemorrhagic fever with renal syndrome (Nephropathia epidemica) in Norway: sereopidemiology 1981–1985. Scand J Infect Dis 1988; 20: 267–74.CrossRefGoogle ScholarPubMed
13Brummer-Korvenkontio, M, Hentonnen, H, Vaheri, A. Hemorrhagic fever with renal syndrome in Finland: Ecology and virology of nephropathia epidemica. Scand J Infect Dis 1982; suppl 36: 8891.Google ScholarPubMed
14.Brummer-Korvenkontio, M, Hedman, K, Vaheri, A. Nephropathia epidemica (NE) in Finland in 1989–1992. Presented at the 2nd International Conference on Haemorrhagic Fever with Renal Syndrome, Beijing, China, 11. 1992.Google Scholar
15.Settergren, B, Ahlm, C, Juto, P, Niklasson, B. Specific Puumala virus IgG half a century after haemorrhagic fever with renal syndrome. Lancet 1991; ii: 338.Google Scholar
16.Li, YL. Cohort study of seroepidemiology on hemorrhagic fever with renal svndrome (in Chinese). Chung Hua Yu Fang I Hsueh Tsa Chi 1991; 25: 329–31.Google Scholar
17.Nyström, K. Incidence and prevalence of endemic benign (epidemic) nephropathy in AC county, Sweden, in relation to population density and prevalence of small rodents. Acad Med Scand 1977; suppl 609: 192.Google ScholarPubMed
18.Lee, HW, Bonwit, C. Hemorrhagic fever – an occupational risk for OSP technicians? WHO Collaborating Centre for Virus Reference and Research (Haemorrhagic fever with renal syndrome). The Institute of Viral Diseases, Korea University, Seoul, Korea, 1991.Google Scholar
19.Xu, Z-Y, Guo, C-S, Wu, Y-L, Zhang, X-W, Liu, K. Epidemiological studies of hemorrhagic fever with renal syndrome: Analysis of risk factors and mode of transmission. J Infect Dis 1985; 152: 137–44.CrossRefGoogle ScholarPubMed
20.Lee, HW, Ahn, CN, Song, JW, Baek, LJ, Seo, TJ, Park, SC. Field trial of an inactivated vaccine against hemorrhagic fever with renal syndrome in humans. Arch Virol 1990; suppl 1: 3547.Google Scholar
21.Song, G, Huang, Y-C, Hang, C-S et al. , Preliminary human trial of inactivated golden hamster kidney cell (GHKC) vaccine against haemorrhagic fever with renal syndrome (HFRS). Vaccine 1992; 10: 214–16.CrossRefGoogle ScholarPubMed
22.Glass, GE, Watson, AJ, LeDuc, JW, Kelen, GD, Quinn, TC, Childs, JE. Infection with a ratborne hantavirus in US residents is consistently associated with hypertensive renal disease. J Infect Dis 1993; 167: 614–20.CrossRefGoogle ScholarPubMed
23.Kleinknecht, D, Rollin, PE. Hypertension after hemorrhagic fever with renal syndrome. Nephron 1992; 61: 121.CrossRefGoogle ScholarPubMed
24.LeDuc, JWT, Childs, JE, Glass, GE. The hantaviruses, etiologic agents of hemorrhagic fever with renal syndrome: a possible cause of hypertension and chronic renal disease in the United States. Annu Rev Public Health 1992; 13: 7998.CrossRefGoogle ScholarPubMed