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Molecular epidemiology of recent United Kingdom isolates of Neisseria meningitidis serogroup C

Published online by Cambridge University Press:  15 May 2009

D. E. Yakubu ,
F. J. R. Abadi  and
T. H. Pennington
D. E. Yakubu
Affiliation:
Department of Medical Microbiology, University of Aberdeen Medical School, Foresterhill, Aberdeen ABO 2ZD
F. J. R. Abadi
Affiliation:
Department of Medical Microbiology, University of Aberdeen Medical School, Foresterhill, Aberdeen ABO 2ZD
T. H. Pennington
Affiliation:
Department of Medical Microbiology, University of Aberdeen Medical School, Foresterhill, Aberdeen ABO 2ZD
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Summary

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The genomes of 34 recent United Kingdom isolates of Neisseria meningitidis serogroup C were examined by restriction enzyme digestion and by conventional and pulsed-field gel electrophoresis (PFGE). Strains were assigned to groups on the basis of the Dice similarity coefficient; strains with values of >92% were considered to be clonally related. Twelve clones were identified by PFGE. Strains of two clonal groups predominated. Restriction endonuclease analyses using the ‘high frequency cleavage’ endonuclease Stu I and conventional electrophoresis gave 11 groups; in general it had lower resolving power than PFGE.

Type
Research Article
Information
Epidemiology & Infection , Volume 113 , Issue 1 , August 1994 , pp. 53 - 65
Copyright
Copyright © Cambridge University Press 1994

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