Epidemiology and Infection

Research Article

Sero/subtyping of Neisseria meningitidis isolated from patients in Spain

J. A. Vazqueza1, C. Marcosa1 and S. Berrona1

a1 Servicio de Bacteriología, Centra Nacional de Microbiologí, Instituto de Salud Carlos III, 28220 Majadahonda (Madrid), Spain


To know the types of meningococcal strains in Spain, we serotyped and subtyped 743 Neisseria meningitidis isolates recovered between 1990 and 1992 from patients. A great number of serogroup B, serogroup C and non-groupable meningoccoci reacted with the serotyping reagents while many serogroup C and non-groupable isolates did not react with the serosubtyping reagents (78·2% and 54·8 % respectively); only 8·9 % of serogroup B meningococci were non-subtypeable (NST). Distribution of serotypes was similar in serogroup C and in non-groupable strains. Isolates showed great variability in antigenic phenotypes (71 in serogroup B, 20 in serogroup C and 25 in non-groupable meningococci). The most frequent antigenic combinations were 4:P1. 15 (39·8%) in serogroup B, 2b:NST (55·8%) in serogroup C and 2b:NST (35·6%) in non-groupable meningococci.

(Accepted May 29 1994)