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Epidemiology of invasive Haemophilus influenzae infections in England and Wales in the pre-vaccination era (1990–2)

Published online by Cambridge University Press:  15 May 2009

E. C. Anderson ,
N. T. Begg ,
S. C. Crawshaw ,
R. M. Hargreaves ,
A. J. Howard  and
M. P. E. Slack
E. C. Anderson
Affiliation:
Oxford Public Health Laboratory, Oxford Radcliffe Hospital, Oxford
N. T. Begg
Affiliation:
PHLS Communicable Disease Surveillance Centre, Colindale
S. C. Crawshaw
Affiliation:
PHLS Communicable Disease Surveillance Centre, Colindale
R. M. Hargreaves*
Affiliation:
Oxford Public Health Laboratory, Oxford Radcliffe Hospital, Oxford
A. J. Howard
Affiliation:
Gwynnedd Hospital, Bangor, North Wales
M. P. E. Slack
Affiliation:
Oxford Public Health Laboratory, Oxford Radcliffe Hospital, Oxford
*
* Author for correspondence: Dr R. M. Hargreaves, Oxford Public Health Laboratory, Oxford Radcliffe Hospital, Headington, Oxford OX3 9DU.
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This survey defined the pattern of invasive Haemophilus influenzae infections during 1990–2 in six regions in England and Wales during the pre-vaccination era providing a baseline against which any changes in patterns of disease due to the introduction of the Haemophilus influenzae type b vaccination programme can be monitored. A total of 946 cases of invasive Haemophilus influenzae were recorded during the survey period of which almost 90 % were due to type b and most of the remainder were non-typeable. Type b infections occurred predominantly in children less than 5 years of age (88%) with the highest attack rate in male infants in the 6–11 month age group. Diagnostic category varied with both age and serotype; meningitis was the commonest presentation overall but pneumonia and bacteraemia were more common in adults and non-typeable isolates. Mortality was highest in neonates and the elderly (over 65 years of age) who were more likely to have an underlying predisposing condition than older children and adults. Children under 5 years of age had a higher case fatality rate for non-typeable than for type b infections. Ampicillin resistance was 15% and there were no cefotaxime resistant type b isolates.

Type
Research Article
Information
Epidemiology & Infection , Volume 115 , Issue 1 , August 1995 , pp. 89 - 100
Copyright
Copyright © Cambridge University Press 1995

References

1.Mäkelä, PH. Takala, AK, Peltola, H, Eskola, J. Epidemiology of invasive Haemophilus influenzae type b disease. J Infect Dis 1992; 165 (suppl 1): S2–6.CrossRefGoogle ScholarPubMed
2.Booy, R, Hodgson, SA, Slack, MPE et al. , Invasive Haemophilus influenzae type b disease in the Oxford Region (1985–1991). Arch Dis Child 1993; 69: 225–8.CrossRefGoogle Scholar
3.Howard, AJ, Dunkin, KT, Muser, JM et al. , Epidemiology of Haemophilus influenzae type b invasive disease: Wales. BMJ 1991; 303: 441–5.CrossRefGoogle ScholarPubMed
4.Wallace, RJ, Muser, DM, Septimus, EJ et al. , Haemophilus influenzae infections in adults: characterisation of strains by serotypes, biotypes and β-lactamase production. J Infect Dis 1981; 144: 101–6.CrossRefGoogle ScholarPubMed
5.Slack, MPE, Crook, DWTM, Jordens, JZ et al. , Molecular and epidemiological aspects of Haemophilus influenzae infection. PHLS Micro Digest 1993; 10: 122–8.Google Scholar
6.Peltola, H, Rod, TO, Jonsdottir, K et al. , Life-threatening Haemophilus influenzae infections in Scandinavia: A five country analysis of the incidence and the main clinical and bacteriological characteristics. Rev Infect Dis 1990; 12: 708–15.CrossRefGoogle Scholar
7.Broome, CV. Epidemiology of Haemophilus influenzae type b infections in the United States. Pediatr Infect Dis J 1987; 6: 799–82.CrossRefGoogle ScholarPubMed
8.Gilbert, GL, Clements, DA, Broughton, SJ. Haemophilus influenzae type b infections in Victoria, Australia 1985–1987. Pediatr Infect Dis J 1990; 9: 252–7.CrossRefGoogle Scholar
9.Hanna, JN. The epidemiology of invasive Haemophilus influenzae infections in children under five vears of age in the Northern Territory: a three year study. Med J Aust 1990; 152: 234–40.CrossRefGoogle Scholar
10.Biljmer, HA, van Alphen, L, Greenwood, BM et al. , The epidemiology of Haemophilus influenzae meningitis in children under five years of age in the Gambia, West Africa. J Infect Dis 1990; 161: 1210–5.Google Scholar
11.Peltola, H, Kilpi, T, Anttila, M. Rapid disappearance of Haemophilus influenzae type b meningitis after routine childhood immunisation with conjugate vaccines. Lancet 1992: 340: 592–4.CrossRefGoogle ScholarPubMed
12.Booy, R, Hodgson, S, Carpenter, L et al. , Efficacy of Haemophilus influenzae type b conjugate vaccine PRP-T. Lancet 1994; 344: 362–6.CrossRefGoogle ScholarPubMed
13.Booy, R, Taylor, SA, Dobson, SRM et al. , Immunogenicity and safety of PRP-T conjugate vaccine given according to the British accelerated immunisation schedule. Arch Dis child 1992; 67: 475–8.CrossRefGoogle Scholar
14.Macleod, CA. Haemophilus influenzae: the efficacy of reporting invasive disease in England and Wales. CDR Rev 1994; 2: R13–6.Google Scholar
15.Nazareth, B, Slack, MPE, Howard, AJ et al. , A survey of invasive Haemophilus influenzae infections. CDR Rev 1992; 2: R13–6.Google ScholarPubMed
16.OPCS statistics 1991: OPCS Provisional estimated resident population mid 1991: population by age and regional health authority.Google Scholar