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Prevalence of human astrovirus serotype 4: capsid protein sequence and comparison with other strains

Published online by Cambridge University Press:  15 May 2009

M. M. Willcocks ,
J. B. Kurtz ,
T. W. Lee  and
M. J. Carter
M. M. Willcocks
Affiliation:
School of Biological Sciences, University of Surrey, Guildford GU2 5XH, UK
J. B. Kurtz
Affiliation:
Virology Laboratory, John Radcliffe Hospital, Headington, Oxford OX3 9DU
T. W. Lee
Affiliation:
Virology Laboratory, John Radcliffe Hospital, Headington, Oxford OX3 9DU
M. J. Carter*
Affiliation:
School of Biological Sciences, University of Surrey, Guildford GU2 5XH, UK
*
* Author for correspondence.
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Summary

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Astrovirus serotype 4 has increased in relative prevalence in the Oxford, UK area in 1993. The structural gene of human astrovirus serotype 4 has been sequenced and the results indicate that this protein differs substantially from serotypes 1 and 2. In particular, conservation at the C terminus is greatly reduced. However, amino acid substitutions in this region show a strong conservation in character suggesting that structural or functional constraints operate in this region.

Type
Research Article
Information
Epidemiology & Infection , Volume 114 , Issue 2 , April 1995 , pp. 385 - 391
Copyright
Copyright © Cambridge University Press 1995

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