a1 School of Biological Sciences, University of Surrey, Guildford GU2 5XH, UK
a2 Virology Laboratory, John Radcliffe Hospital, Headington, Oxford OX3 9DU
Astrovirus serotype 4 has increased in relative prevalence in the Oxford, UK area in 1993. The structural gene of human astrovirus serotype 4 has been sequenced and the results indicate that this protein differs substantially from serotypes 1 and 2. In particular, conservation at the C terminus is greatly reduced. However, amino acid substitutions in this region show a strong conservation in character suggesting that structural or functional constraints operate in this region.
(Accepted October 27 1994)
c1 Author for correspondence.