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Thermal sensitivity of Clostridium botulinum type C toxin

Published online by Cambridge University Press:  15 May 2009

Z. Hubálek  and
J. Halouzka
Z. Hubálek
Affiliation:
Czechoslovak Academy of Sciences, Institute of Systematical and ecological
J. Halouzka
Affiliation:
Czechoslovak Academy of Sciences, Institute of Systematical and ecological
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A sterile suspension containing 950 mouse LD50 per ml of type C botulinum toxin was exposed for various periods to different temperatures. The time required for the 99% (hundred-fold) reduction of toxicity was more than 5 years at -70°C or -20°C, 6 montha at +5 °C, 3 weeks at +20 °C, 2 weeks at +28 °C, 2 days at +37 °C, 9h at +42°C, less than 30 min at 56 °C, less than 20 min at +60 °C, and below 5 min at +80 °C. The results suggest that Clostridium botulinum type C toxin, if produced in an ecosystem of the mild climatic zone, might persist there over the winter season and cause the intoxication of vertebrates next carly spring in the absence of further microbial toxigenesis.

Type
Research Article
Information
Epidemiology & Infection , Volume 101 , Issue 2 , October 1988 , pp. 321 - 325
Copyright
Copyright © Cambridge University Press 1988

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