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Vaccination with live type 4 adenovirus: evaluation of antibody response and protective efficacy

Published online by Cambridge University Press:  15 May 2009

J. Van Der Veen ,
M. F. W. Abarbanel  and
Kiem Giok Oei
J. Van Der Veen
Affiliation:
Department of Medical Microbiology, University of Nijmegen, Nijmegen, The Netherlands
M. F. W. Abarbanel
Affiliation:
Department of Medical Microbiology, University of Nijmegen, Nijmegen, The Netherlands
Kiem Giok Oei
Affiliation:
Department of Medical Microbiology, University of Nijmegen, Nijmegen, The Netherlands
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Live type 4 adenovirus contained in enteric-coated tablets was given to 2628 military recruits. In two trials, the enteric adenovirus vaccine reduced febrile and afebrile adenovirus illness by about 90% or more. Moreover, a decided protective effect against subclinical adenovirus infection as evidenced by seroconversion was found.

The antibody-stimulating effect of enteric adenovirus vaccine was not an adequate measure of its protective capacity. The neutralizing antibody response of recruits given vaccine was poor in comparison with the antibody response to naturally acquired infection with type 4 adenovirus. The latter response was related to the severity of infection.

We are indebted to Colonel Dr B. J. W. Beunders, Head of the Division of Preventive Medicine of the Royal Netherlands Army, for granting us facilities to conduct this study and to Misses W. T. C. J. Smulders, E. M. J. C. Vallas, J. E. M. Dusseldorp and M. M. J. P. Keeris for their valuable technical assistance.

Type
Research Article
Information
Journal of Hygiene , Volume 66 , Issue 4 , December 1968 , pp. 499 - 511
Copyright
Copyright © Cambridge University Press 1968

References

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